Nick Dickenson

Publications | Book Chapters

• Adam, P., Barta, M., Dickenson, N., (2015). Characterization of Type Three Secretion System Translocator Interactions with Phospholipid Membranes: Type 3 Secretion Systems: Methods and Protocols. Springer Publishing Company *
• Barta, M., Adam, P., Dickenson, N., (2015). Recombinant Expression and Purification of the Shigella Translocator IpaB: Type 3 Secretion Systems: Methods and Protocols. Springer Publishing Company *
• Arizmendi, O., Dickenson, N., (2015). Dissecting Shigella flexneri Type III Secretion System Tip Complex Maturation: Shigella: Molecular and Cellular Biology. Caister Academic Press *
• Dickenson, N., Mooren, O.L, Erickson, E.S, Dunn, R.C, (2014). Near-Field Scanning Optical Microscopy: A New Tool for Exploring Biological Structure and Function: Surface Analysis and Techniques in Biology. *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Barker, S.A, Ellis, P., Hammer, A., Johnson, S.J, Dickenson, N.E, (2026). Structural and Biophysical Characterization of the Yersinia Type Three Secretion System ATPase YscN. Proteins: Structure, Function, and Bioinformatics, doi: 10.1002/prot.70112
• A, S.B, K, P.E, Hammer, A., Johnson, S., Dickenson, N., (2025). Structural and Biophysical Characterization of the Yersinia Type Three Secretion System ATPase YscN. Wiley, Authorea, doi: 10.22541/au.176359530.02438941/v1 *
• Barker, S.A, Bernard, A.R, Morales, Y., Johnson, S.J, Dickenson, N.E, (2024). Structural and functional characterization of the IpaD π-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence. Journal of Biological Chemistry, 300:9, doi: 10.1016/j.jbc.2024.107613
• Case, H.B, Gonzalez, S., Gustafson, M.E, Dickenson, N.E, (2023). Differential Regulation of Shigella Spa47 ATPase Activity by a Native C-terminal Product of Spa33. Frontiers in Cellular and Infection Microbiology - Molecular Bacterial Pathogenesis, 13:2023, doi: 10.3389/fcimb.2023.1183211
• Hardy, K.D, Dickenson, N.E, (2022). Phosphomimetic Tyrosine Mutations in Spa47 Inhibit Type Three Secretion ATPase Activity and Shigella Virulence Phenotype. Pathogens, 11:2, doi: https://doi.org/10.3390/pathogens11020202
• Dickenson, N.E, (2021). Past, present, and future: Dissecting the bacterial type III secretion system. Physics of Life Reviews, 39, 82-84.
• Case, H.B, Mattock, D.S, Miller III, B., Dickenson, N.E, (2020). Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Shigella Effector Secretion. Biochemistry, 59:28, 2667-2678. doi: 10.1021/acs.biochem.0c00431
• Burgess, J.L, Case, H.B, Burgess, R.A, Dickenson, N., (2020). Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence. PLOS ONE, 15:1, e0228227. doi: https://doi.org/10.1371/journal.pone.0228227
• Demler, H.J, Case, H.B, Morales, Y., Bernard, A.R, Johnson, S.J, Dickenson, N., (2019). Interfacial Amino Acids Support Spa47 Oligomerization and Shigella Type Three Secretion System Activation. Proteins, 87:11, 931-942. doi: 10.1002/prot.25754
• Case, H.B, Mattock, D.S, Dickenson, N., (2018). Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors. Biochemistry, 57:50, 6906-6916. doi: 10.1021/acs.biochem.8b01077
• Case, H.B, Dickenson, N., (2018). Kinetic Characterization of the Shigella Type Three Secretion System ATPase Spa47 Using α-32P ATP. Bio-protocol, 8:21, e3074. doi: 10.21769/BioProtoc.3074
• Case, H., Dickenson, N., (2018). MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47. Biochemistry, 57:15, 2266-2277. doi: 10.1021/acs.biochem.8b00070
• Bernard, A.R, Jessop, T.C, Kumar, P., Dickenson, N., (2017). Deoxycholate-Enhanced Shigella Virulence Is Regulated by a Rare π-Helix in the Type Three Secretion System Tip Protein IpaD. Biochemistry, 56:49, 6503-6514. doi: 10.1021/acs.biochem.7b00836
• Han, G., Jin, Y., Burgess, R.A, Dickenson, N., Cao, X., Sun, Y., (2017). Visible-Light-Driven Valorization of Biomass Intermediates Integrated with H2 Production Catalyzed by Ultrathin Ni/CdS Nanosheets. Journal of the American Chemical Society, 139:44, 15584-15587.
• Burgess, J.L, Burgess, R.A, Morales, Y., Bouvang, J.M, Johnson, S.J, Dickenson, N., (2016). Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. Journal of Biological Chemistry, 291:50, 25837-25852. doi: 10.1074/jbc.M116.755256
• Bernard, A.R, Duarte, S., Kumar, P., Dickenson, N., (2016). Detergent isolation stabilizes and activates the Shigella type III secretion system translocator protein IpaC. Journal of Pharmaceutical Science, 105:7
• Burgess, J.L, Jones, H.B, Kumar, P., Toth, R., Middaugh, C., Antony, E., Dickenson, N., (2016). Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. Protein Science, 25, 1037-1048.
• Chen, X., Choudhari, S., Martinez, F., Kim, J., Dickenson, N., Toth, R., Joshi, S., Greenwood, J., Clements, J., Picking, W., Middaugh, C., Picking, W., (2015). Impact of detergent on the biophysical properties and immune response of the IpaDB Fusion protein, a candidate subunit vaccine against Shigella spp. Infection and Immunity, 83:1, 292-299. doi: 10.1128/IAI
• Adam, P.R, Dickenson, N., Greenwood 2nd, J.C, Picking, W.L, Picking, W.D, (2014). Influence of Oligomerization State on the Structural Properties of Invasion Plasmid Antigen B (IpaB) from Shigella flexneri in the Presence and Absence of Phospholipid Membranes. PROTEINS: Structure, Function, and Bioinformatics
• Martinez-Becerra, F.J, Chen, X., Dickenson, N., Choudhari, S.P, Harrison, K., Clements, J.D, Picking, W.D, Van De Verg, L.L, Walker, R.I, Picking, W.L, (2013). Characterization of a novel fusion protein of IpaB and IpaD of Shigella and its potential as a pan-Shigella vaccine. Infection and Immunity
• Schonknecht, G., Chen, W., Ternes, C.M, Barbier, G.G, Shrestha, R.P, Stanke, M., Brautigam, A., Baker, B.J, Banfield, J.F, Garavito, R.M, Benning, C., Carr, K., Wilkerson, C., Rensing, S.A, Gagneul, D., Dickenson, N., Oesterhelt, C., Lercher, M.J, Weber, A.P, (2013). Gene Transfer from Bacteria and Archaea Facilitated Evolution of an Extremophilic Eukaryote. Science, 339(6124), 1207-1210.
• Dickenson, N., Choudhari, S., Adam, P.R, Kramer, R.M, Joshi, S.B, Middaugh, C.R, Picking, W.L, Picking, W.D, (2013). Oligomeric States of the Shigella Translocator Protein IpaB Provide Structural Insights into Formation of the Type III Secretion Translocon. Protein Science, 22(5), 614-27.
• Dickenson, N., Arizmendi, O., Patil, M., Picking, W.D, Picking, W.L, (2013). The N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD. Biochemistry, 52:49, 8790-8799.
• Lotlikar, S.R, Hnatusko, S.B, Dickenson, N., Choudhari, S.P, Picking, W.L, Patrauchan, M.A, (2013). Three functional carbonic anhydrases in P. aeruginosa PAO1. Role in survival in ambient air. Microbiology, 159:8, 1748-1759.
• Adam, P.R, Patil, M., Dickenson, N., Barta, M.L, Choudhari, S., Geisbrecht, B.V, Picking, W.L, Picking, W.D, (2012). Binding Affects the Tertiary and Quaternary Structures of the Shigella Translocator Protein IpaB and its Chaperone IpgC. Biochemistry, 51, 4062-4071.
• Dickenson, N., Picking, W.D, (2012). FRET as a tool for dissecting molecular interactions within the bacterial type III secretion needle tip complex. International Journal of Molecular Sciences, 13(11), 15137-15161.
• Barta, M.L, Dickenson, N., Patil, M., Picking, W.D, Picking, W.L, Geisbrecht, B.V, (2012). The crystal structures of coiled-coil domains from type three secretion system first translocator proteins reveal homology to pore-forming toxins. Journal of Molecular Biology, 417(5), 395-405.
• Epler, C.R, Dickenson, N., Bullitt, E., Picking, W.L, (2012). Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri. Journal of Molecular Biology, 420, 29-39.
• Dickenson, N., Zhang, L., Epler, C.R, Adam, P.R, Picking, W.L, Picking, W.D, (2011). Conformational Changes in IpaD from Shigella flexneri Upon Binding Bile Salts Provide Insight into the Second Step of Type III Secretion. Biochemistry, 50, 172-180.
• Barta, M.L, Guragain, M., Adam, P.R, Dickenson, N., Geisbrecht, B.V, Picking, W.L, Picking, W.D, (2011). Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure. Proteins, 80(3), 935-945.
• Dickenson, N., Armendariz, K.P, Huckabay, H.A, Livanec, P.W, Dunn, R.C, (2010). Near-field scanning optical microscopy: a tool for nanometric exploration of biological membranes. Analytical and Bioanalytical Chemistry, 396:1, 31-43.
• Epler, C.R, Dickenson, N., Olive, A.J, Picking, W.L, Picking, W.D, (2009). Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction. Infection and Immunity, 77:7, 2754-61.
• Dickenson, N., Erickson, E.S, Mooren, O.L, Dunn, R.C, (2007). Characterization of Power Induced Heating and Damage in Fiber Optic Probes for Near-Field Scanning Optical Microscopy. Review of Scientific Instruments, 78, 53712-53716.
• Dickenson, N., Moore, D., Suprenant, K.A, Dunn, R.C, (2007). Vault Ribonucleoprotein Particles and the Central Mass of the Nuclear Pore Complex. Photochemistry and Photobiology, 83, 1-6.
• Mooren, O.L, Erickson, E.S, Dickenson, N., Dunn, R.C, (2006). Extending Near-Field Scanning Optical Microscopy for Biological Studies. Journal of the Association for Laboratory Automation, 11, 268- 272.

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.