Sean Johnson

Publications | Abstracts

• Kuznetsov, V.I, Johnson, S.J, Hengge, A.C, (2012). High resolution structure of the phosphatase VHZ explains unexpectedsubstrate specificity, and suggests the presence of metavanadate at theactive site. FASEB JOURNAL *
• Huefner, S.A, Brandao, T.A, Johnson, S.J, Hengge, A.C, (2008). CHED 176-Protein-tyrosine phosphatases: Comparing the effects ofmutation on protein conformation and catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *
• Brandao, T.A, Huefner, S.A, Johnson, S.J, Hengge, A.C, (2008). BIOL 97-Protein conformational changes in catalysis by protein-tyrosinephosphatases. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Book Chapters

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Barker, S.A, Ellis, P., Hammer, A., Johnson, S.J, Dickenson, N.E, (2026). Structural and Biophysical Characterization of the Yersinia Type Three Secretion System ATPase YscN. Proteins: Structure, Function, and Bioinformatics, doi: 10.1002/prot.70112
• Hengge, A.C, Johnson, S.J, (2025). Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase. JACS Au, doi: https://doi.org/10.1021/jacsau.5c00756
• Barker, S.A, Bernard, A.R, Morales, Y., Johnson, S.J, Dickenson, N.E, (2024). Structural and functional characterization of the IpaD π-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence. Journal of Biological Chemistry, 300:9, doi: 10.1016/j.jbc.2024.107613
• Shen, R., Crean, R.M, Olsen, K.J, Corbella, M., Calixto, A.R, Richan, T., Brandão, T.A, Berry, R.D, Tolman, A., Loria, J.P, Johnson, S.J, Kamerlin, S.C, Hengge, A.C, (2022). Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem. Sci., 13524-13540. doi: https://doi.org/10.1039/D2SC04135A
• Shen, R., Crean, R.M, Johnson, S.J, Kamerlin, S.C, Hengge, A.C, (2021). Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. JACS Au, 1:5, 646-659.
• Demler, H.J, Case, H.B, Morales, Y., Bernard, A.R, Johnson, S.J, Dickenson, N., (2019). Interfacial Amino Acids Support Spa47 Oligomerization and Shigella Type Three Secretion System Activation. Proteins, 87:11, 931-942. doi: 10.1002/prot.25754
• Moise, G., Morales, Y., Beaumont, V., Caradonna, T., Loria, J.P, Johnson, S.J, Hengge, A.C, (2018). A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57:36, 5315-5326.
• Morales, Y., Olsen, K.J, Bulcher, J.M, Johnson, S.J, (2018). Structure of Frequency-interacting RNA Helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. PLoS ONE, 13:5, e0196642. doi: 10.1371/journal.pone.0196642
• Burgess, J.L, Burgess, R.A, Morales, Y., Bouvang, J.M, Johnson, S.J, Dickenson, N., (2016). Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. Journal of Biological Chemistry, 291:50, 25837-25852. doi: 10.1074/jbc.M116.755256
• Moise, G., Gallup, N.M, Alexandrova, .N, Hengge, A.C, Johnson, S.J, (2015). Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54:42, 6490-6500. doi: 10.1021/acs.biochem.5b00496
• Losh, J.S, King, A.K, Bakelar, J., Taylor, L., Loomis, J., Rosenzweig, J.A, Johnson, S.J, van Hoof, A., (2015). Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing. Nucelic Acids Research, 43:3, 1848-1858. doi: 10.1093/nar/gkv005
• Taylor, L., Jackson, R.N, Rexhepaj, M., King, A.K, Lott, L.K, van Hoof, A., Johnson, S.J, (2014). The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding. Nucelic Acids Research, 42:22, 13861-13872. doi: 10.1093/nar/gku1208
• Bakelar, J.W, Sliwa, D.A, Johnson, S.J, (2013). Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases. Archives of Biochemistry and Biophysics, 533:1-2, 62-68. doi: doi.org/10.1016/j.abb.2013.02.017
• Zeng, J., Lytle, A.K, Gage, D., Johnson, S.J, Zhan, J., (2013). Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase. Bioorganic and Medicinal Chemistry Letters, 23:4, 1001-1003. doi: 10.1016/j.bmcl.2012.12.038
• Johnson, S.J, Jackson, R.N, (2013). Structures of Ski2-like RNA helicases: common themes and complex assemblies. RNA Biology, 10:1, 33-43. doi: http://dx.doi.org/10.4161/rna.22101
• Kuznetsov, V.I, Hengge, A.C, Johnson, S.J, (2012). New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening. Biochemistry, 51:49, 9869-9879. doi: 10.1021/bi300908y
• Brandao, T.A, Johnson, S.J, Hengge, A.C, (2012). The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Archives of Biochemistry and Biophysics, 525:1, 53-59. doi: doi.org/10.1016/j.abb.2012.06.002
• Schaeffer, D., Reis, F.P, Johnson, S.J, Arraiano, C.M, van Hoof, A., (2012). The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function. Nucleic Acids Research, 40:18, 9298-9307. doi: 10.1093/nar/gks693
• Gui, L., Wooderchak, W.L, Daly, M.P, Porter, P.J, Johnson, S.J, Hevel, J.M, (2011). Investigation of the Molecular Origins of Protein Arginine Methyltransferase I (PRMT1) Product Specificity Reveals a Role for Two Conserved Methionine Residues. Journal of Biological Chemistry, 286:33, 29118-26. doi: 10.1074/jbc.M111.224097
• Close, D., Johnson, S.J, Sadano, M.A, McDonald, S.M, Robinson, H., Formosa, T., Hill, C.P, (2011). Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. Journal of Molecular Biology, 408:4, 697-713. doi: doi.org/10.1016/j.jmb.2011.03.002
• Hintze, B.J, Johnson, S.J, (2010). ResDe: A New Tool for Visual Definition of Distance Restraints for Crystallographic Refinement. The Journal of Applied Crystallography, 6, 1540-1542. doi: 10.1107/S0021889810038689
• Jackson, R.N, Klauer, A.A, Hintze, B.J, Robinson, H., van Hoof, A., Johnson, S.J, (2010). The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. The EMBO Journal, 29, 2205-2216. doi: 10.1038/emboj.2010.107
• Brandao, T.A, Hengge, A.C, Johnson, S.J, (2010). Insights into the reaction of protein tyrosine phosphatase 1B. Crystal structures for transition-state analogs of both catalytic steps. Journal of Biological Chemistry, 285:21, 15874-15883. doi: 10.1074/jbc.M109.066951
• Brandao, T.A, Robinson, H., Johnson, S.J, Hengge, A.C, (2008). Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. Journal of the American Chemical Society, 131:2, 778-786. doi: 10.1021/ja807418b
• Johnson, S.J, Close, D., Robinson, H., Vallet-Gely, I., Dove, S.L, Hill, C.P, (2008). Crystal Structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. Journal of Molecular Biology, 377:5, 1460-1473. doi: 10.1016/j.jmb.2008.01.096
• Johnson, S.J, Beese, L.S, (2004). Structures of mismatch replication errors observed in a DNA polymerase. Cell, 116:6, 803-816. doi: 10.1016/S0092-8674(04)00252-1
• Johnson, S.J, Taylor, J.S, Beese, L.S, (2003). Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. Proceedings of the National Academy of Sciences USA, 100, 3895-3900. doi: 10.1073/pnas.0630532100

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.