Erin Bobeck

Publications | Journal Articles

Academic Journal

• Bobeck, E.N, (2025). ProSAAS neuropeptides and receptors GPR171 and GPR83: Potential therapeutic applications for pain, anxiety, and body weight regulation. Journal of Pharmacology and Experimental Therapeutics392(6):103599, doi: 10.1016/j.jpet.2025.103599
• Bobeck, E.N, (2023). A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice. Pharmacology, Biochemistry & Behavior, 224:173543, doi: 10.1016/j.pbb.2023.173543
• Afrose, L., McDermott, M.V, Bhuiyan, A.I, Pathak, S.K, Bobeck, E.N, (2022). GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice.. Behavioural Pharmacology, 33:7, 442-451. doi: 10.1097/FBP.0000000000000692
• Schoo, S.M, Bobeck, E.N, Morgan, M.M, (2018). Enhanced antinociception with repeated microinjections of apomorphine into the periaqueductal gray of male and female rats.. Behavioural pharmacology
• Bobeck, E.N, Gomes, I., Pena, D., Cummings, K.A, Clem, R.L, Mezei, M., Devi, L.A, (2017). The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42:13, 2527-2536.
• Wardman, J.H, Gomes, I., Bobeck, E.N, Stockert, J.A, Kapoor, A., Bisignano, P., Gupta, A., Mezei, M., Kumar, S., Filizola, M., Devi, L.A, (2016). Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.. Science signaling, 9:430, ra55.
• Gupta, A., Gomes, I., Bobeck, E.N, Fakira, A.K, Massaro, N.P, Sharma, I., Cavé, A., Hamm, H.E, Parello, J., Devi, L.A, (2016). Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.. Proceedings of the National Academy of Sciences of the United States of America, 113:21, 6041-6.
• Gomes, I., Bobeck, E.N, Margolis, E.B, Gupta, A., Sierra, S., Fakira, A.K, Fujita, W., Müller, T.D, Müller, A., Tschöp, M.H, Kleinau, G., Fricker, L.D, Devi, L.A, (2016). Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.. Science signaling, 9:425, ra43.
• Bobeck, E.N, Ingram, S.L, Hermes, S.M, Aicher, S.A, Morgan, M.M, (2016). Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.. Behavioural brain research, 298:Pt B, 17-24.
• Macey, T.A, Bobeck, E.N, Suchland, K.L, Morgan, M.M, Ingram, S.L, (2015). Change in functional selectivity of morphine with the development of antinociceptive tolerance.. British journal of pharmacology, 172:2, 549-61.
• Gupta, A., Fujita, W., Gomes, I., Bobeck, E.N, Devi, L.A, (2015). Endothelin-converting enzyme 2 differentially regulates opioid receptor activity.. British journal of pharmacology, 172:2, 704-19.
• Bobeck, E.N, Chen, Q., Morgan, M.M, Ingram, S.L, (2014). Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39:9, 2142-52.
• Bobeck, E.N, Haseman, R.A, Hong, D., Ingram, S.L, Morgan, M.M, (2012). Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.. The journal of pain : official journal of the American Pain Society, 13:8, 799-807.
• Gunn, A., Bobeck, E.N, Weber, C., Morgan, M.M, (2011). The influence of non-nociceptive factors on hot-plate latency in rats.. The journal of pain : official journal of the American Pain Society, 12:2, 222-7.
• Macey, T.A, Ingram, S.L, Bobeck, E.N, Hegarty, D.M, Aicher, S.A, Arttamangkul, S., Morgan, M.M, (2010). Opioid receptor internalization contributes to dermorphin-mediated antinociception.. Neuroscience, 168:2, 543-50.
• Bobeck, E.N, McNeal, A.L, Morgan, M.M, (2009). Drug dependent sex-differences in periaqueducatal gray mediated antinociception in the rat.. Pain, 147:1-3, 210-6.
• Macey, T.A, Bobeck, E.N, Hegarty, D.M, Aicher, S.A, Ingram, S.L, Morgan, M.M, (2009). Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat.. The Journal of pharmacology and experimental therapeutics, 331:2, 412-8.
• Morgan, M.M, Bobeck, E.N, Ingram, S.L, (2009). Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat.. Brain research, 1295, 59-66.
• Ingram, S.L, Macey, T.A, Bobeck, E.N, Morgan, M.M, (2008). Tolerance to repeated morphine administration is associated with increased potency of opioid agonists.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33:10, 2494-504.
• Bobeck, E.N, Lisowski, M.J, Macey, T.A, Ingram, S.L, Morgan, M.M, (2008). Microinjection of the vehicle dimethyl sulfoxide (DMSO) into the periaqueductal gray modulates morphine antinociception.. Brain research, 1204, 53-8.
• Meyer, P.J, Bobeck, E.N, Ingram, S.L, Morgan, M.M, (2007). Analgesic tolerance to microinjection of the micro-opioid agonist DAMGO into the ventrolateral periaqueductal gray.. Neuropharmacology, 52:8, 1580-5.
• Ingram, S.L, Bobeck, E.N, Morgan, M.M, (2007). Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32:3, 600-6.
• Morgan, M.M, Bobeck, E.N, Levine, C.S, Ingram, S.L, (2006). Antinociceptive tolerance revealed by cumulative intracranial microinjections of morphine into the periaqueductal gray in the rat.. Pharmacology, biochemistry, and behavior, 85:1, 214-9.
• Morgan, M.M, Bobeck, E.N, Stalding, B.M, King, M.M, (2006). Morphine antinociceptive potency on chemical, mechanical, and thermal nociceptive tests in the rat.. The journal of pain : official journal of the American Pain Society, 7:5, 358-66.
• Bobeck, E.N, Narrative review of the scientific and methodological explanations for 101 mechanisms of opioid tolerance. Pain reports

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.